WILLIAM B. BLYTHE, M.D.
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The clinical expression of parenchymal renal disease is a broad continuum, with stages ranging from one in which there are no symptoms or physical findings—and is thus detectable only by laboratory examination—to one in which there is a constellation of gastrointestinal, neuromuscular, cardiovascular, and other manifestations. This wide spectrum is usually divided into three phases: an asymptomatic phase, a symptomatic phase in which there is clinical evidence of disturbance of various organ systems, and the ultimate clinical expression, uremia.
During this past decade it has become possible to define more precisely the various clinical manifestations as a consequence not only
BLYTHE WB. Severity of Established Renal Disease: Criteria for Evaluation. Ann Intern Med. ;75:315. doi: 10.7326/0003-4819-75-2-315
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Published: Ann Intern Med. 1971;75(2):315.
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