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It is 10 years since Davis and his associates have shown that decapitation of hypophysectomized dogs does not alter aldosterone secretion nor prevent a marked increase in aldosterone output in response to hemorrhage. Since then it has been popularly assumed that the reninangiotensin system is the primary regulator of aldosterone secretion. This issue is not yet settled satisfactorily, however. Whereas in man and experimental animals aldosterone secretion continues in the complete absence of the pituitary glands, many investigators have found that hypophysectomy or spontaneous hyperpituitarism results in an impaired aldosterone secretion under basal conditions or under various physiological stimuli.
Regulation of Aldosterone Biosynthesis.. Ann Intern Med. 1971;75:331. doi: 10.7326/0003-4819-75-2-331_2
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Published: Ann Intern Med. 1971;75(2):331.
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