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For almost 100 years dimethyl sulfoxide (DMSO) was known as a solvent with many useful commercial properties. In 1964 a wide range of its pharmacologic actions were described by Jacob, one of the editors of this volume, and Herschler. Its biologic properties of penetrability promised to enrich the methods of administration of various medications; to the oral, rectal, topical, and various injectable parenteral routes, the possibility of carrying substances through the skin by first dissolving them in DMSO and then topically applying the resultant mixture was added. Moreover, DMSO by itself seems to possess antiinflammatory properties; reports of usefulness in
Basic Concepts of DMSO.. Ann Intern Med. ;75:335. doi: 10.7326/0003-4819-75-2-335_2
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Published: Ann Intern Med. 1971;75(2):335.
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