C. J. GLUECK, M.D.; R. I. LEVY, M.D.; D. S. FREDRICKSON, M.D.
Norethindrone acetate, a synthetic progestagen, was given to 5 normal persons and 26 patients with familial types I, III, IV, and V hyperlipoproteinemia. Triglyceride levels fell in all women with type V, in some males with type V, and in 9 of 13 patients with types III and IV hyperlipoproteinemia. Triglycerides did not fall in the two patients with familial type I hyperlipoproteinemia. Decrements in triglyceride induced by norethindrone acetate were often associated with simultaneous increments in postheparin lipolytic activity and postheparin triglyceride lipase. Triglyceride clearing was most marked in those women with type V, whose low postheparin lipolytic activity was elevated into the normal range during therapy.
GLUECK CJ, LEVY RI, FREDRICKSON DS. Norethindrone Acetate, Postheparin Lipolytic Activity, and Plasma Triglycerides in Familial Types I, III, IV, and V Hyperlipoproteinemia: Studies in 26 Patients and 5 Normal Persons. Ann Intern Med. ;75:345–352. doi: 10.7326/0003-4819-75-3-345
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Published: Ann Intern Med. 1971;75(3):345-352.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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