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For several thousand years physicians have observed "fevers," described them, used them in diagnosis and prognosis, and worried about their treatment. About one hundred years ago it was proposed that fever represented a disorder of the temperature-regulating mechanism in the central nervous system. But major studies into the mechanism of fever production have taken place only during the past 20 years. The current belief is that certain substances (for example, high molecular weight lipopolysaccharides from the cell walls of Gram-negative bacteria, or certain steroids) interact with blood leukocytes and induce them to release a pyrogen, which in turn acts on
Pyrogens and Fever.. Ann Intern Med. 1971;75:652–653. doi: https://doi.org/10.7326/0003-4819-75-4-652_2
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Published: Ann Intern Med. 1971;75(4):652-653.
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