PAUL H. DUFFEY, M.D., F.A.C.P.; HAROLD C. TRETBAR, M.D.; THADDEUS L. JARKOWSKI, M.D.
While undergoing experimental sodium fluoride therapy for osteoporosis, an elderly woman was found to have giant cells in her bone marrow that did not fit any previous description. Two other patients taking fluoride for osteoporosis had identical cells in their marrows. The cells disappeared on discontinuing the drug therapy. We have not seen giant cells of this type in previous cases of osteoporosis of similar severity or in any other bone marrows studied.
DUFFEY PH, TRETBAR HC, JARKOWSKI TL. Giant Cells in Bone Marrows of Patients on High-Dose Fluoride Treatment. Ann Intern Med. 1971;75:745–747. doi: https://doi.org/10.7326/0003-4819-75-5-745
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Published: Ann Intern Med. 1971;75(5):745-747.
Endocrine and Metabolism, Geriatric Medicine, Hematology/Oncology, Metabolic Bone Disorders.
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