KARL D. NOLPH, M.D., F.A.C.P.; MICHAEL L. STOLTZ, M.D.; JOHN F. MAHER, M.D., F.A.C.P.
Decreased peritoneal membrane permeability should impair the transperitoneal diffusion of larger molecular weight solutes more than that of smaller solutes during peritoneal dialysis. To see if systemic vascular disease produces such selective functional alterations in man, peritoneal clearances of urea (Curea), creatinine (Ccr) and urate (Curate) were measured in four patients with severe systemic vascular disease. Mean values for Curea, Ccr/Curea, and Curate/Curea in the study patients were significantly (P < 0.01) below values for these functions in the control group. The selective reductions in the clearances of higher molecular weight solutes suggest alterations of functional permeability of the peritoneal capillaries or mesothelium, or both, in patients with systemic vascular disease.
NOLPH KD, STOLTZ ML, MAHER JF. Altered Peritoneal Permeability in Patients with Systemic Vasculitis. Ann Intern Med. ;75:753–755. doi: 10.7326/0003-4819-75-5-753
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Published: Ann Intern Med. 1971;75(5):753-755.
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