VICTOR HERBERT, M.D.
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To the editor: In his excellent review "Vitamin B12-Binding Proteins of Man" (ANNALS 75:297-301, 1971), Dr. Hall discussed "Vitamin B12 binders useful in diagnosis." Your readers should perhaps be made aware that evidence exists that a significant portion of B12-binding protein derives from leukocytes (1-3), and it is probably for this reason that measurement of vitamin B12-binding protein is of diagnostic value in assessing the existence of myeloproliferative disorders and their response to therapy.
Vitamin B12-binding protein seems to correlate with the total blood granulocyte pool (3), and measures said pool rather than measuring the existence of a hematologic malignancy.
HERBERT V. B12- Binding Protein. Ann Intern Med. 1971;75:808–809. doi: 10.7326/0003-4819-75-5-808_2
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Published: Ann Intern Med. 1971;75(5):808-809.
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