JERALD C. NELSON, M.D.; DELORES E. JOHNSON, M.D.; WILLIAM D. ODELL, M.D. Ph.D.
The correlation between serum levels of human thyrotrophin (HTSH) and thyroidal response to bovine thyrotrophin (BTSH) stimulation was studied in patients with nontoxic thyroid disorders. All patients with primary hypothyroidism had elevated HTSH levels and either absent or borderline response to BTSH stimulation. Euthyroid patients with thyroid disease fell into four categories: normal HTSH and normal stimulation by BTSH; normal HTSH and no stimulation by BTSH; elevated HTSH and normal stimulation by BTSH; and elevated HTSH and no stimulation by BTSH. In some diffuse goiter patients there was a dissociation between the protein-bound iodine response and the radioactive iodine response to BTSH. There was no evidence of a "short-loop" feedback suppression of HTSH by BTSH. Elevated HTSH levels in goitrous patients may not necessarily indicate either hypothyroidism or a loss of normal responsiveness to BTSH stimulation.
NELSON JC, JOHNSON DE, ODELL WD. Serum TSH Levels and the Thyroidal Response to TSH Stimulation in Patients with Thyroid Disease. Ann Intern Med. ;76:47–52. doi: 10.7326/0003-4819-76-1-47
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Published: Ann Intern Med. 1972;76(1):47-52.
Endocrine and Metabolism, Thyroid Disorders.
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