E. BOURKE, M.D.; G. FRINDT, M.D.; PAULINE FLYNN, B.A.; G. E. SCHREINER, M.D., F.A.C.P.
A 10-year-old girl with primary hyperoxaluria, calcium oxalate nephrolithiasis, and normal blood urea was studied. Despite high urinary oxalate and glycolate excretion, normal activity of α-ketoglutarate:glyoxylate carboligase was observed in both mitochondria-containing and soluble cytoplasmic fractions of striated muscle tissue. No effect on the urinary excretion of oxalate or glycolate was observed with the administration of pyridoxine, allopurinol, or calcium carbimide. A 40% reduction in urinary oxalate excretion was produced by isocarboxazid therapy. Further studies are necessary to elucidate the role of monoamine oxidase inhibitors in the treatment of primary hyperoxaluria.
BOURKE E, FRINDT G, FLYNN P, et al. Primary Hyperoxaluria with Normal Alpha-Ketoglutarate:Glyoxylate Carboligase Activity: Treatment with Isocarboxazid. Ann Intern Med. 1972;76:279–284. doi: https://doi.org/10.7326/0003-4819-76-2-279
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Published: Ann Intern Med. 1972;76(2):279-284.
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