JAMES C. MELBY, M.D.
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To the editor: Dr. M. H. Maxwell states in the UCLA Conference, "Hypertension—Primary and Secondary" (Ann Intern Med 75:761-776, 1971), that "about 20% of all patients with so-called essential hypertension have suppressed plasma renin activity. This has been unexplained, but it is exciting that investigators are finding that most of these patients have an excess of 18-hydroxydeoxycorticosterone." Although Dr. Maxwell does not refer specifically to the published evidence for this assertion, my colleagues and I have, for the past few years, been measuring metabolites of 18-OH-DOC in the urine of patients with low renin hypertension and find that not more
MELBY JC. Excess 18-Hydroxydeoxycorticosterone: Most or Some?. Ann Intern Med. ;76:334. doi: 10.7326/0003-4819-76-2-334_1
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Published: Ann Intern Med. 1972;76(2):334.
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