STANLEY ZUCKER, M.D.; C. HAROLD MIELKE JR., M.D.; JOHN R. DUROCHER, M.D.; WILLIAM H. CROSBY, M.D.
This report describes 6 unrelated patients with mild bleeding disorders caused by abnormalities of platelet function. This syndrome has its onset in childhood and has one or more of these characteristics: easy bruising, spontaneous bleeding from mucosal membranes, excessive bleeding after minor or major surgery, and menorrhagia. Coagulation tests in these patients showed a prolonged bleeding time and a delayed and diminished platelet aggregation response to epinephrine and collagen. The platelet count, platelet adhesiveness, platelet factor-3 release, and factor VIII activity were usually normal. Pedigree studies suggested an autosomal-dominant mode of inheritance. An experimental trial of prednisone therapy in five patients resulted in significant improvement in the bleeding time, yet platelet aggregation test results were unaltered.
ZUCKER S, MIELKE CH, DUROCHER JR, et al. Oozing and Bruising Due to Abnormal Platelet Function (Thrombocytopathia): A Family Study of the Syndrome. Ann Intern Med. 1972;76:725–731. doi: 10.7326/0003-4819-76-5-725
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Published: Ann Intern Med. 1972;76(5):725-731.
Emergency Medicine, Hematology/Oncology, Platelet Disorders.
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