Edward C. Franklin, M.D.
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All immunoglobulins consist of two types of polypeptide chains (heavy and light chains) that appear to be under separate genetic control. Certain neoplastic disorders of plasma cells and lymphocytes are accompanied by the production of homogeneous immunoglobulins. Among these disorders are myeloma, macroglobulinemia, and the group of heavy chain diseases. Study of the proteins produced has provided clear insights into the biosynthesis and assembly of immunoglobulins, has uncovered evidence of unbalanced synthesis of heavy and light chains, and has demonstrated the existence of deletions in some of the proteins. Not infrequently these proteins can be shown to possess antibody activity,
Franklin EC. Structures and Function of Immunoglobulins and Some Disorders of Synthesis.. Ann Intern Med. 1972;76:853. doi: https://doi.org/10.7326/0003-4819-76-5-853_4
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Published: Ann Intern Med. 1972;76(5):853.
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