Thomas E. Starzl, M.D., Ph.D.
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The four major immunosuppressants in clinical use today are azathioprine, cyclophosphamide, prednisone, and antilymphocytic globulin—used in combinations of two or three agents.
After organ transplantation the maximum requirement for treatment with these drugs is usually during the first few post-operative weeks. If this dangerous phase of convalescence can be negotiated, the homograft often appears to be "accepted" in a relative sense so that heavy maintenance immunosuppression is not required. Thereafter, good chronic transplant function may continue in a patient who has retained the ability to deal with inimical environmental antigens, including pathogenic bacteria, and who therefore may now return in
Starzl TE. Transplantation Immunology.. Ann Intern Med. 1972;76:854. doi: https://doi.org/10.7326/0003-4819-76-5-854_3
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Published: Ann Intern Med. 1972;76(5):854.
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