Philip Felig, M.D., F.A.C.P.; Edward S. Horton, M.D.; Carl F. Runge, M.D.; Ethan A. H. Sims, M.D., F.A.C.P.
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Insulin modulates plasma levels of specific amino acids by regulating their outflow from peripheral protein reservoirs, particularly muscle. In spontaneous, severe obesity, hyperaminoacidemia has been demonstrated and may be a manifestation of insulin resistance. To evaluate further the interaction of insulin and amino acid metabolism in obesity, the effect of insulin on amino acid exchange across the forearm was studied in five subjects at ideal weight and after a 17 to 25% (16 kg) weight gain induced by over-eating and limited physical activity. Sixteen individual plasma amino acid levels were measured in simultaneous forearm arterial and deep venous (draining primarily
Felig P, Horton ES, Runge CF, et al. Experimental Obesity in Man: Hyperaminoacidemia and Diminished Effectiveness of Insulin in Regulating Peripheral Amino Acid Release.. Ann Intern Med. 1972;76:857. doi: https://doi.org/10.7326/0003-4819-76-5-857_4
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Published: Ann Intern Med. 1972;76(5):857.
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