J. R. Givens, M.D.; W. L. Wiser, M.D.; R. N. Anderson, Ph.D.; R. S. Wilroy, M.D.; S. A. Coleman, M.D.; S. A. Fish, M.D.
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This study documented hyperandrogenism in 18 hirsute women and determined if the condition was gonadotropin dependent. Plasma androstenedione, testosterone, and luteinizing hormone (LH) were measured by radioimmunoassay. All had 24-hour urinary 17-ketosteroids, 17-ketogenic steroids, and pregnanetriol measured, and those with Cushing's syndrome and congenital adrenal hyperplasia we e excluded from the study. Six underwent bilateral longitudinal ovarian wedge resection and had polycystic ovarian disease. The mean plasma androstenedione of 18 patients was 332 ng/100 ml (SE ± 24.6 ng/100 ml). The normal mean androstenedione is 180 ng/100 ml. Mean plasma testosterone was 77 ng/100 ml (±12.2). The normal range for
Givens JR, Wiser WL, Anderson RN, Wilroy RS, Coleman SA, Fish SA. Suppression of Plasma Androstenedione and Testosterone in Hirsute Women.. Ann Intern Med. ;76:858. doi: 10.7326/0003-4819-76-5-858_1
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Published: Ann Intern Med. 1972;76(5):858.
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