Robert J. Kucera, M.S.; Martin G. Durkin, M.D.
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Increased gastric acid output and elevation of serum gastrin levels are characteristic features of the Zollinger-Ellison syndrome. Variation in acid output in this disorder is well known; recently we have observed marked spontaneous variation in serum gastrin levels. In our patient the serum gastrin concentration ranged from 400 to 13 000 pg/ml.
To further evaluate possible mechanisms that might control gastrin release in this disorder and thus permit differentiation from the normal, the effects of antral acidification, prolonged intragastric infusion of antacid, the response to feeding, insulin-induced hypoglycemia, and secretin administration were studied. Serum gastrin levels were measured by radioimmunoassay.
Kucera RJ, Durkin MG. Variation in Serum Gastrin Levels in Zollinger-Ellison Syndrome.. Ann Intern Med. ;76:860. doi: 10.7326/0003-4819-76-5-860_2
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Published: Ann Intern Med. 1972;76(5):860.
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