W. Pruzanski, F.R.C.P. (C); R. E. Warren, F.R.C.P. (C); J. Goldie, F.R.C.P. (C); A. Katz, M.D.
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A 68-year-old woman had fatigue, vomiting, and abdominal cramps for 15 months, ankle edema for 3 months, and severe diarrhea for 3 weeks. Physical examination showed a pale lethargic woman with ascites and ankle edema. There was no organomegaly or lymphadenopathy. Hemoglobin was 9.0 mg/100 ml; serum albumin, 1.9 g/100 ml; calcium, 6.8 mg/100 ml; prothrombin time, 17 sec; carotene, 17 μg/100 ml; xylose absorption, 3.4 g/5 hr; fecal fat excretion, 12 g/24 hr; 51Cr chloride excretion, 8.6%. Serum electrophoresis showed an M component of 1.76 g/100 ml, identified as an 19S IgM(λ). Urine contained 560 mg/24 hr of protein
Pruzanski W, Warren RE, Goldie J, et al. Malabsorption Associated with Infiltration of the Intestinal Wall by a Homogeneous IgM (λ). A Syndrome of Macroglobulinosis.. Ann Intern Med. 1972;76:861. doi: 10.7326/0003-4819-76-5-861_1
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Published: Ann Intern Med. 1972;76(5):861.
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