James E. Doherty, M.D., F.A.C.P.; William J. Flanigan, M.D., F.A.C.P.; Robert L. Clark, M.D.; Marvin L. Murphy, M.D., F.A.C.P.
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Fifty-four human volunteers were given tritiated digoxin by the oral or intravenous route, or both, to determine absorption, excretion, enterohepatic circulation, and serum turnover rates. Frequent serum samples were obtained, and all stools and urine were saved for 7 days. Bile was also saved from six patients with surgically induced biliary fistula who received the drug intravenously. Specimens were extracted by column chromatography and samples counted with a liquid scintillation counter. A mean serum T½ of 33 hours was observed in those patients with normal renal function. Excretory data are shown below.
Digoxin was 85% absorbed, and enterohepatic circulation was
Doherty JE, Flanigan WJ, Clark RL, et al. Studies with Tritiated Digoxin: Absorption, Excretion, and Enterohepatic Circulation.. Ann Intern Med. 1972;76:862–863. doi: https://doi.org/10.7326/0003-4819-76-5-862_4
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Published: Ann Intern Med. 1972;76(5):862-863.
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