James Forrester, M.D.; William Bezdek, M.D.; Kanu Chatterjee, M.D.; Paul Levin, M.D.; William W. Parmley, M.D., F.A.C.P.; H. J. C. Swan, M.D., F.A.C.P.
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Since the use of digitalis in acute myocardial infarction remains controversial, hemodynamic data were obtained in 16 patients within 48 hours of acute myocardial infarction before and at ½-hour intervals for 2 hours after receiving a bolus intravenous dose of either 0.4 to 0.5 mg ouabain or 0.5 to 0.75 mg digoxin. In patients who showed hemodynamic changes, maximum response was at 30 to 60 min.
Although some improvement in left ventricular function was noted in patients with uncomplicated myocardial infarction, hemodynamic changes in all three groups were small. Only four of 16 patients had a greater than 15% increase
Forrester J, Bezdek W, Chatterjee K, et al. Hemodynamic Effects of Digitalis in Acute Myocardial Infarction.. Ann Intern Med. 1972;76:863–864. doi: 10.7326/0003-4819-76-5-863_4
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Published: Ann Intern Med. 1972;76(5):863-864.
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