J. I. Haft, M.D., F.A.C.P.; P. D. Kranz, M.D.; K. Gershengorn, M.D.; F. J. Albert, M.D.; R. Oestreicher, M.D.; K. Fani, M.D.
This content is PDF only. Please click on the PDF icon to access.
Sympathetic catecholamines will cause aggregation of platelets in vitro. Infusion of catecholamines in the experimental animal will result in necrosis in the myocardium. In order to determine if this cardiac necrosis is caused in part by the intravascular aggregation of platelets, two studies involving pretreatment with drugs known to inhibit platelet aggregation and the electron microscopic demonstration of platelet thrombi in cardiac capillaries were undertaken.
Thirty dogs were infused with epinephrine 4 g/kg body weight·min for 4 hours. Ten were pretreated with aspirin, 10 gr b.i.d.; 10 with dipyridamole, 50 mg b.i.d., for 4 days; and 10 served as controls.
Haft JI, Kranz PD, Gershengorn K, et al. Intravascular Platelet Aggregation on the Heart Induced In Vivo by Catecholamine Infusion.. Ann Intern Med. 1972;76:864–865. doi: 10.7326/0003-4819-76-5-864_4
Download citation file:
Published: Ann Intern Med. 1972;76(5):864-865.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use