Dalius J. Briedis; Janifer Judisch, M.D.; Henry N. Watner Jr., M.D., F.A.C.P.; Patricia A. McIntyre, M.D., F.A.C.P.
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The diagnosis of pernicious anemia (PA) by radioisotope tracer techniques depends on evidence of malabsorption of radioactive vitamin B12, which is improved by intrinsic factor (IF). In this study the dual isotope method for the diagnosis of pernicious anemia was evaluated. Thirty-seven patients and 74 control subjects were simultaneously given 0.5 μg of 58Co-labeled free cyanocobalamin (B12) and 0.5 μg of [57Co] B12 bound to normal human gastric juice. Twenty-four-hour urine specimens and 8-hour plasma specimens were obtained, and the isotopes were differentially counted. Patients with pernicious anemia showed significant differences between urinary excretions of the two isotopes, control subjects
Briedis DJ, Judisch J, Watner HN, et al. Vitamin B12 Absorption Tests: An Evaluation.. Ann Intern Med. 1972;76:869. doi: 10.7326/0003-4819-76-5-869_2
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Published: Ann Intern Med. 1972;76(5):869.
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