Martin C. Mihm, M.D.; Stanley J. Robboy; John D. Minna, M.D.; Robert W. Colman, M.D., F.A.C.P.
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In a prospective study of 45 patients with disseminated intravascular coagulation, cutaneous manifestations heralded the onset of the syndrome in 33% and eventually appeared in 88% of the patients. Purpura and petechiae were the commonest lesions, although other important but generally unrecognized manifestations included palpable purpura (16%), purpura fulminans or gangrene (16%), acrocyanosis (15%), and hemorrhagic bullae (9%). In two cases nasal cyanosis that progressed to gangrene was associated with digital acrocyanosis. Histologic studies showed that fibrin thrombi in small cutaneous vessels were diagnostic features shared by lesions of all ages. Early lesions showed fibrin thrombi and hemorrhage but little
Mihm MC, Robboy SJ, Minna JD, et al. The Skin in Disseminated Intravascular Coagulation.. Ann Intern Med. 1972;76:870. doi: https://doi.org/10.7326/0003-4819-76-5-870_2
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Published: Ann Intern Med. 1972;76(5):870.
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