Marvin J. Stone, M.D.; Eugene P. Frenkel, M.D., F.A.C.P.
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Light chain disease is a common form of myeloma that is frequently difficult to recognize because of its variable clinical features and the absence of a monoclonal spike on routine serum protein electrophoresis. During the past 29 months 24 patients with light chain disease were seen; these constituted 25% of all the identified myeloma patients. The commonest initial manifestations were bone pain and progressive renal failure. Four patients had amyloidosis, and five others had plasmacytomas. One patient had no symptoms or signs referable to his plasma cell dyscrasia. Many of the anticipated features of classical myeloma were absent; thus, physician
Stone MJ, Frenkel EP. The Clinical Spectrum of Light Chain Myeloma.. Ann Intern Med. 1972;76:871. doi: https://doi.org/10.7326/0003-4819-76-5-871_3
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Published: Ann Intern Med. 1972;76(5):871.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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