Hewitt C. Goodpasture, M.D.; Douglas W. Voth, M.D.; D. A. Romig, M.D.; D. Cheng, M.D.; B. D. Wenglin, M.D.; Chien Liu, M.D., F.A.C.P.
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Fifteen patients treated with amphotericin B for systemic fungal infection (histoplasmosis, five; sporotrichosis, three; aspergillosis, two; cryptococcosis, two; coccidioidomycosis, two; and blastomycosis, one) were selected for special studies. The drug was given in dosages of up to 1 mg/kg body weight day according to the degree of reduction in glomerular filtration rate. Local and systemic intestinal, hematopoietic, hepatic, endocrine, neuromuscular, renal, and cardiopulmonary side effects of the drug were sought by clinical and laboratory observations performed before, during, and after treatment
Fever, chills, weakness, and nausea occurred regularly but were less severe as treatment continued. This "tolerance" was not predictable
Goodpasture HC, Voth DW, Romig DA, et al. Clinical Correlations During Amphotericin B Therapy.. Ann Intern Med. 1972;76:872. doi: 10.7326/0003-4819-76-5-872_2
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Published: Ann Intern Med. 1972;76(5):872.
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