Jae C. Chang, M.D.; Thomas C. Hall, F.A.C.P.
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In vitro, the effects of plasma from patients with malignant neoplasms who were not receiving radiation and chemotherapy were studied on DNA and RNA synthesis from 14C-thymidine (TdR), 3H-deoxyuridine (UdR), and 14C-uridine (UR) in day-5 L1210 mouse ascites leukemic cells. Plasma at the concentration of 10% from three of 20 patients showed 50% to 90% inhibition of TdR incorporation into DNA, 50% to 75% UdR into DNA, and 70% to 98% UR into RNA. These plasmas from three patients showed uniform inhibition of all DNA and RNA synthesis without specific depression on any particular pathway, which is suggestive of the
Chang JC, Hall TC. A Factor Inhibiting Nucleic Acid Synthesis in Plasma of Patients with Malignant Neoplasms.. Ann Intern Med. 1972;76:876. doi: 10.7326/0003-4819-76-5-876_2
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Published: Ann Intern Med. 1972;76(5):876.
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