W. H. Knospe, M.D., F.A.C.P.; S. A. Gregory, M.D.; F. E. Trobaugh Jr., M.D., F.A.C.P.; R. Schrek, M.D.
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Chronic lymphocytic leukemia varies in severity of course, and in prognosis and response to therapy. Thirty-five patients with chronic lymphocytic leukemia were studied over the past 3 years, 18 patients until death. Survival varied from 9 months to 11 years with median survival of 3½ years. Ten patients had an indolent course, and the others had an active or fulminant course. Hematologic and morphologic study of lymphocytes was supplemented with electron microscopy and a variety of in vitro treatments of cultured lymphocytes. Difficulty in classifying cells by size on peripheral blood smear lead to the use of electron microscopic morphology,
Knospe WH, Gregory SA, Trobaugh FE, et al. Electron Microscopy and In Vitro Testing of Chronic Lymphocytic Leukemic Lymphocytes for Clinical Classification, Prognosis, and Prediction of Therapeutic Response.. Ann Intern Med. 1972;76:877. doi: https://doi.org/10.7326/0003-4819-76-5-877_2
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Published: Ann Intern Med. 1972;76(5):877.
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