Gary L. Huber, M.D.; F. Marc LaForce, M.D.; John F. Mullane, M.D.
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Impaired liver function is frequently accompanied by alterations in lung structure and function. In addition, pulmonary infection is a frequent cause of morbidity and mortality in patients with liver disease. To study the relationship between liver damage and pulmonary function, liver impairment was experimentally induced using two rat animal models: common bile duct ligation and partial hepatectomy. To study pulmonary host defenses in these animals, bacterial in situ inactivation in the lungs was evaluated 14 hours after an aerosolized challenge of radiolabeled (32P) Staphylcoccus aureus. Control rats inactivated 86.3% of the bacterial challenge. After ligation of the common bile duct,
Huber GL, LaForce FM, Mullane JF. The Effect of Liver Impairment of Lung Function and Pulmonary Antibacterial Defenses.. Ann Intern Med. ;76:879–880. doi: 10.7326/0003-4819-76-5-879_4
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Published: Ann Intern Med. 1972;76(5):879-880.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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