R. S. Pascual, M.D.; P. E. Perillie, M.D.; S. Sulavik, M.D.; J. A. Donadio, M.D.; J. B. L. Gee, M.D., F.A.C.P.; S. C. Finch, M.D.
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The clinical significance of lysozymuria and increased serum lysozyme activity was evaluated in 41 patients with proved sarcoid. Lysozyme activity was determined by either the lysoplate or turbidimetric method. All patients were staged according to chest radiographic findings. Most had total and differential white cell counts, blood urea nitrogen, and serum calcium determinations. Lysozymuria was present in 15 of 41 patients (37%), and lysozyme activity was increased in 14 of 23 (61%). All five patients with obvious splenic involvement had increased lysozyme activity. All patients with increased activity had early infiltrative lung disease with hilar adenopathy. Successful corticoid therapy was
Pascual RS, Perillie PE, Sulavik S, et al. Lysozyme Studies in Sarcoidosis.. Ann Intern Med. 1972;76:880. doi: https://doi.org/10.7326/0003-4819-76-5-880_3
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Published: Ann Intern Med. 1972;76(5):880.
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