JOHN E. CONTE JR., M.D.; STEPHEN N. COHEN, M.D.; BENSON B. ROE, M.D.; ROBERT M. ELASHOFF, Ph.D.
A prospective, double-blind study was carried out to evaluate two prophylactic regimens in patients undergoing cardiac surgery with cardiopulmonary bypass. The first group received 1 g of cephalothin during surgery and 20 doses of intravenous placebo preoperatively and postoperatively. A second group received the intraoperative antibiotic plus 20 1-g doses of intravenous cephalothin preoperatively and postoperatively. There were no significant differences between the two groups in major and minor infections, deaths, or floral changes. The longer course of prophylaxis may have influenced adversely the species of organisms causing major infection.
CONTE JE, COHEN SN, ROE BB, ELASHOFF RM. Antibiotic Prophylaxis and Cardiac Surgery: A Prospective Double-Blind Comparison of Single-Dose Versus Multiple-Dose Regimens. Ann Intern Med. ;76:943–949. doi: 10.7326/0003-4819-76-6-943
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Published: Ann Intern Med. 1972;76(6):943-949.
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