JOSE L. CAMPRA, M.D.; JOHN R. CRAIG, M.D., Ph.D.; ROBERT L. PETERS, M.D.; TELFER B. REYNOLDS, M.D., F.A.C.P.
A 63-year-old woman developed ascites that led to a diagnosis of cryptogenic cirrhosis. Eosinophilic cytoplasmic inclusions were found in hepatocytes on examination of liver biopsy specimens and were shown by immunofluorescent staining to be deposits of alpha-1 antitrypsin. She had a partial deficiency of serum alpha-1 antitrypsin, with a SZ phenotype for the Pi (protease inhibitor) system. Severe, homozygous alpha-1 antitrypsin deficiency is known to be associated with juvenile cirrhosis; we propose that a partial deficiency may be related to liver disease in adults.
CAMPRA JL, CRAIG JR, PETERS RL, et al. Cirrhosis Associated with Partial Deficiency of Alpha-1 Antitrypsin in an Adult. Ann Intern Med. 1973;78:233–238. doi: https://doi.org/10.7326/0003-4819-78-2-233
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Published: Ann Intern Med. 1973;78(2):233-238.
Gastroenterology/Hepatology, Liver Disease.
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