STUART C. SCHEER, M.D.
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To the editor: With reference to the excellent editorial on subacute myelo-optico-neuropathy (SMON) by Dr. Erland Nelson (Ann Intern Med 77:468-470, 1972), I wish to point out that clioquinol (5-chloro-7-iodo-8-quinolinol), the drug linked in Japan with SMON, probably sounds to most American physicians like some obscure chemical.
For those unfamiliar with the name clioquinol, which is a proposed, international nonproprietary name, the generic name used in the United States is lodochlorhydroxyquin, which is marketed under the trade name Entero-Vioform® (Ciba).
Iodochlorhydroxyquin has been and still is commonly prescribed by physicians for the prevention and treatment of travelers' diarrhea. The drug
SCHEER SC. Clioquinol, Iodochlorhydroxyquin. Ann Intern Med. 1973;78:309. doi: https://doi.org/10.7326/0003-4819-78-2-309_1
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Published: Ann Intern Med. 1973;78(2):309.
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