R. W. AMMANN, M.D.; J. EDWARD BERK, M.D., F.A.C.P.; LOUIS FRIDHANDLER; MASATOSHI UEDA, M.D.; W. WEGMANN, M.D.
Two patients with pronounced hyperamylasemia and hyperamylasuria, associated with metastatic carcinoma of the lung, are described. The primary lung tumor in the one patient with tissue available for assay contained adrenocorticotrophin and had a pronounced degree of amylase activity. Ion exchange chromatography further showed that the motility pattern of the amylase in the serum, urine, and tumor tissue of this patient resembled salivary amylase. Assay of metastatic lesions in both patients showed amylase activity levels that exceeded those in the serum. These observations indicate that amylase may be produced ectopically in some carcinomatous lung tumors and that amylase of this origin may cause pronounced and persistent hyperamylasemia.
AMMANN RW, BERK JE, FRIDHANDLER L, et al. Hyperamylasemia with Carcinoma of the Lung. Ann Intern Med. 1973;78:521–525. doi: https://doi.org/10.7326/0003-4819-78-4-521
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Published: Ann Intern Med. 1973;78(4):521-525.
Hematology/Oncology, Lung Cancer, Pulmonary/Critical Care.
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