MICHAEL F. ELMORE, M.D.; LAWRENCE D. RINK, M.D.; J. PETER RISSING, M.D.
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To the editor: We commend Menda and Gorbach on their approach to the treatment of bacterial endocarditis (Ann Intern Med 78:25-32, 1973). In their 23 cases, 11 of 16 with Staphylococcus aureus had solitary tricuspid involvement, and all 11 had septic pulmonary emboli. Five were treated with cephalothin (12 g/day), and two failed to respond despite the fact that the organisms were sensitive to a minimal inhibitory concentration of less than 1 µg/ml; both patients subsequently responded to clindamycin therapy, but one of the patients required an additional 6-week course of clindamycin after a relapse. We report a similar case.
ELMORE MF, RINK LD, RISSING JP. Clindamycin, Endocarditis, Hepatotoxicity. Ann Intern Med. ;78:779–780. doi: 10.7326/0003-4819-78-5-779_3
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Published: Ann Intern Med. 1973;78(5):779-780.
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