Julian Davies, M.D.
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The continued use of antibiotics in clinical practice has provided strong pressure for the selection of bacteria resistant to these antibiotics. The bacterial strains generally owe their resistance characteristics to genetically transmissible agents called R-factors. Studies have shown that R-factors determine the synthesis of several enzymes that specifically inactivate antibiotics. The enzymatic inactivations often give rise to cross-resistance to several antibiotics because the enzymes can use structural elements common to several antibiotics as their substrates. The introduction of new antibiotics that lack these structural elements has provided agents active against some resistant bacterial strains. Once again, however, the selection of
Davies J. Bacteria Versus Antibiotics: Who Is Winning?. Ann Intern Med. 1973;78:813. doi: https://doi.org/10.7326/0003-4819-78-5-813_6
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Published: Ann Intern Med. 1973;78(5):813.
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