Avram Goldstein, M.D.
This content is PDF only. Please click on the PDF icon to access.
To understand fully the way any drug produces its pharmacologic effects, we have to learn not only where it acts (what organs, tissues, and cells are primarily affected) but also exactly what it does at the site(s) of action. Considerable progress is being made in identifying and isolating drug receptors-the macro-molecules with which drugs interact to initiate the sequence of biochemical changes that ultimately produce the characteristic drug effect in the whole organism.
The opioid narcotics are of particular interest for their ability to produce tolerance and physical dependence, which play a role in the addiction process. In this lecture
Goldstein A. Molecular Aspects of Narcotic Addiction.. Ann Intern Med. 1973;78:813. doi: https://doi.org/10.7326/0003-4819-78-5-813_7
Download citation file:
Published: Ann Intern Med. 1973;78(5):813.
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use