Avram Goldstein, M.D.
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To understand fully the way any drug produces its pharmacologic effects, we have to learn not only where it acts (what organs, tissues, and cells are primarily affected) but also exactly what it does at the site(s) of action. Considerable progress is being made in identifying and isolating drug receptors-the macro-molecules with which drugs interact to initiate the sequence of biochemical changes that ultimately produce the characteristic drug effect in the whole organism.
The opioid narcotics are of particular interest for their ability to produce tolerance and physical dependence, which play a role in the addiction process. In this lecture
Goldstein A. Molecular Aspects of Narcotic Addiction.. Ann Intern Med. ;78:813. doi: 10.7326/0003-4819-78-5-813_7
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Published: Ann Intern Med. 1973;78(5):813.
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