G. T. Stricklan, M.D., F.A.C.P.; D. Frommer, M.D.; M-L. Leu, M.D.; R. Pollard, M.S.; S. Sherlock, M.D., F.A.C.P.(Hon.); J. N. Cumings, M.D.
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Wilson's disease has genetic heterogeneity with variations in clinical symptoms among families as well as races and countries. Chinese females had an early onset of symptoms (mean, 11.8 years) and death (mean, 13.9 years), whereas Chinese had later onset (mean, 20.9 years) and age at death (mean, 23.2 years). British patients showed a similar trend, with females having earlier onset of symptoms (mean, 14.9 years) than males (mean, 16.8 years). Males in predominantly female-affected families usually, had early onset, whereas females in predominantly male-affected families had late onset. Twenty-five of 30 patients with onset of symptoms at age 20 years
Stricklan GT, Frommer D, Leu M, et al. Wilson's Disease in the United Kingdom and Taiwan. I. General Characteristics of 142 Cases and Prognosis with Penicillamine Therapy.. Ann Intern Med. 1973;78:816. doi: 10.7326/0003-4819-78-5-816_2
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Published: Ann Intern Med. 1973;78(5):816.
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