Joseph B. Hollis; Raymond L. Farrell, M.D.; Donald O. Castell, M.D., F.A.C.P.
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Gastrin has been shown to have a specific stimulatory effect on lower esophageal sphincter pressure, and this hormone is believed to be the main determinant of resting sphincter pressure. Recently, the predictable elevated sphincter pressures in hypergastrinemic patients with Zollinger-Ellison syndrome have been shown. Therefore, esophageal function in pernicious anemia patients with elevated serum gastrin levels is of particular interest. We have studied both lower esophageal sphincter and esophageal peristalsis in a group of pernicious anemia patients and age-matched controls. With an infused open-tipped system, mean sphincter resting pressure was 14.8 ± 0.9 (± SE) mm Hg for controls and
Hollis JB, Farrell RL, Castell DO. Esophageal Dynamics in Hypergastrinemic Pernicious Anemia Patients.. Ann Intern Med. ;78:817. doi: 10.7326/0003-4819-78-5-817_3
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Published: Ann Intern Med. 1973;78(5):817.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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