B. von Hartitzsch, M.D.; J. W. Eaton, Ph.D.; C. M. Kjellstrand, M.D.; T. J. Buselmeier, M.D.
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Recent information indicates that blood transfusions, which may induce hepatitis, bone marrow suppression, and isoimmune stimulation are unwarranted in the treatment of anemia of renal failure. Elevated serum phosphate levels, as well as hypoxia, stimulate enhanced red cell 2, 3-diphosphoglycerate (DPG) synthesis, with DPG concentration higher than those reported for similar anemias of other causes. Despite their low hemoglobin concentrations, the blood of these patients gives up almost as much oxygen per volume of whole blood as the blood of normal persons. The anemia of renal failure may be owing to the lack of hypoxic stimulus due to enhanced oxygen
von Hartitzsch B, Eaton JW, Kjellstrand CM, et al. "Anemia" of Renal Failure: A Physiological Adaptation.. Ann Intern Med. 1973;78:822–823. doi: https://doi.org/10.7326/0003-4819-78-5-822_4
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Published: Ann Intern Med. 1973;78(5):822-823.
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