Anthony Melaragno, B.S.; Patrick W. Flanigan, M.D.; Philip A. Bromberg, M.D., F.A.C.P.; Stanley P. Balcerzak, M.D., F.A.C.P.
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Cyanate therapy of sickle-cell disease is currently under investigation. Since cyanate-treated erythrocytes have increased oxygen affinity, we studied the effect of chronic cyanate administration on tissue oxygen delivery in rats. Sodium cyanate (CNO) was administered for 8 weeks to two groups of rats. Thirty received 625 mg/kg body weight-week orally, and 30 received 250 mg/kg body weight-week intraperitoneally. Control animals received equivalent amounts of NaCl. Animals were killed at 2, 4, and 8 weeks, and blood oxygen affinity (P50), erythrocyte 2, 3-diphosphoglycerate (DPG), hematocrit, and erythrocyte mass were measured. Tissue oxygen delivery was assessed by skin bubble oxygen tension (SBpO2).
Melaragno A, Flanigan PW, Bromberg PA, et al. Impaired O2 Delivery in Cyanate-Treated Animals.. Ann Intern Med. 1973;78:823. doi: https://doi.org/10.7326/0003-4819-78-5-823_2
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Published: Ann Intern Med. 1973;78(5):823.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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