Robert M. Nalbandian, M.D.; Bruce M. Nichols, B.S.; Noyes L. Avery Jr, M.D., F.A.C.P.; COL Frank R. Camp Jr
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Urea in sugar solutions has been experimentally and clinically effective in the sickle-cell disease because of its demonstrated reversal and blocking actions on sickled erythrocytes. This beneficial effect has been attributed to the formation of cyanate in vivo and subsequent carbamylation of beta S globin chains. By controlled studies in oxygen-free atmospheres we have found that SS cells, protected from sickling by urea-sugar solutions (blood urea nitrogen level of 140 mg/100 ml), were again sickled after the addition of urease, which had no such effect on carbamylated cells.
Urea blocks and reverses sickling; urea-protected cells are
sickled by urease treatment;
Nalbandian RM, Nichols BM, Avery NL, et al. Urea, Urease, Cyanate and the Sickling of Hemoglobin S.. Ann Intern Med. 1973;78:823–824. doi: 10.7326/0003-4819-78-5-823_4
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Published: Ann Intern Med. 1973;78(5):823-824.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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