Larry W. Rumans, M.D.; Douglas W. Voth, M.D.; Sharon P. Wagoner; Chien Liu, M.D., F.A.C.P.
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Measurement of serum concentrations of potentially toxic antibiotics, especially in patients with compromised renal function, is desirable for optimal therapy. The applicability of nomograms based on renal function for estimating drug dosage has been emphasized by others; by comparing predicted with observed drug concentrations the usefulness of the nomograms can be tested. A 4-hour microassay, based on a well-diffusion method, was developed for the quantitative determination of aminoglycoside drugs, for example, gentamicin. Wells (5 mm) were cut in trypticase soy agar plates (100 mm x 15 mm), which were preseeded with Bacillus globigii. Thirty-picolitre serum samples were distributed in the
Rumans LW, Voth DW, Wagoner SP, et al. Clinical Value of A New Antibiotic Assay.. Ann Intern Med. 1973;78:826–827. doi: 10.7326/0003-4819-78-5-826_5
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Published: Ann Intern Med. 1973;78(5):826-827.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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