D. Churchill, M.D.; M. H. Gault, M.D., F.A.C.P.; J. Knaack, M.D.; C. Cole, M.D., F.A.C.P.; R. C. Muehrcke, M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
Persistent renal dysfunction followed methoxyflurane anaesthesia in 2 patients. Each was elderly and had received 0.2% methoxyflurane for slightly longer than 4 hours. One developed polyuria, hypernatremia, and azotemia, postoperatively. Serum creatinine rose from 0.9 mg/100 ml, preoperatively, to a peak value of 2.9 mg/100 ml on the 8th postoperative day. Ffteen months after surgery the 24-hr creatinine clearance averaged 36 ml/ min, and maximum osmolality was 424 mosmol/kg of water after dehydration and vasopressin, The second patient had a slow rise in serum creatinine from 1.1 mg/100 ml before surgery to a peak value of 7.5 mg/100 ml on
Churchill D, Gault MH, Knaack J, et al. Persistent Renal Failure Following Methoxyflurane Anaesthesia.. Ann Intern Med. 1973;78:827. doi: 10.7326/0003-4819-78-5-827_1
Download citation file:
Published: Ann Intern Med. 1973;78(5):827.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use