Kenneth A. McKusick, M.D.; Peter T. Kirchner, M.D.; Leon Malmud, M.D.; Melville Williams, M.D.; Henry N. Wagner Jr., M.D., F.A.C.P.; T. K. Natarajan
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A fall in renal blood flow has been shown to be one of the earliest pathophysiologic signs of renal graft rejection. Computer-assisted regional quantitation of serial gamma camera images of the kidney, after intravenous injection of 10 mCi 99mTc-diethylenetriaminepentacetic acid, provides both an accurate measure of renal blood transit time and a quantitative index of total renal blood flow.
Radioactivity over abdominal aorta and the transplant was continuously recorded with a gamma camera onto magnetic tape, in consecutive 3-sec intervals for the first minute. After light pen selection of regions of interest from the serial images, time activity curves were
McKusick KA, Kirchner PT, Malmud L, Williams M, Wagner HN, Natarajan TK. The Radioisotopic Differentiation of Acute Tubular Necrosis from Rejection in Clinical Renal Transplantation.. Ann Intern Med. 1973;78:827. doi: 10.7326/0003-4819-78-5-827_2
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Published: Ann Intern Med. 1973;78(5):827.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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