Subhash C. Gulati, M.D.; E. Victor Adlin, M.D., F.A.C.P.; C. Miller Biddle, M.D.; Allan D. Marks, M.D.; Bertram J. Channick, M.D., F.A.C.P.
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To determine the relation of low plasma renin activity in hypertension to the development of vascular complications, 201 patients with essential hypertension, who had previously had measurements of plasma renin activity and aldosterone excretion rate, were surveyed for myocardial infarction or cerebrovascular accident. Patients with renovascular hypertension, malignant hypertension, and primary or secondary aldosteronism were excluded. Plasma renin activity was measured after the stimulus of upright posture plus a low sodium diet. One hundred and sixteen patients had normal activity and were diagnosed as having normal-renin essential hypertension. Eighty-five patients had low activity and were diagnosed as having low-renin essential
Gulati SC, Adlin EV, Biddle CM, et al. The Occurrence of Vascular Complications in Low Renin Hypertension.. Ann Intern Med. 1973;78:828. doi: 10.7326/0003-4819-78-5-828_3
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Published: Ann Intern Med. 1973;78(5):828.
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