Thomas Hoeppner, Ph.D.; Frank Morrell, M.D.; Jo Ann Hoeppner
This content is PDF only. Please click on the PDF icon to access.
This study presents a preliminary examination of the relation between skin scarring and posttraumatic epilepsy.
Penfield has pointed out that in the meningocerebral cicatrix, which so commonly results from cerebral trauma, fibroblasts of mesodermal origin invade the brain tissue. Unlike scars of purely glial origin, those derived from mesodermal tissue contract and thus distort neuronal architecture, placing continuous tension on surrounding neural elements. Such mechanical deformation has been shown to produce partial dendritic depolarization, thereby sharply increasing excitability and producing sustained, high-frequency firing. It seems reasonable to suppose that a tendency to form exaggerated hypertrophic scars would be highly correlated
Hoeppner T, Morrell F, Hoeppner JA. Skin Scarring, Epilepsy, and Genetics.. Ann Intern Med. 1973;78:829–830. doi: 10.7326/0003-4819-78-5-829_3
Download citation file:
Published: Ann Intern Med. 1973;78(5):829-830.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use