J. R. Bianchine, M.D., F.A.C.P.; T. H. Hsu, M.D.; T. J. Preziosi, M.D.; F. S. Messiha, Ph.D.
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Pyridoxine when coadministered with levodopa to parkinsonian patients may negate levodopa's therapeutic effect. Since pyridoxal 5-phosphate is a cofactor for transaminase and dopa-decarboxylase, it may accelerate levodopa metabolism. To test this possible explanation for this therapeutic impairment, we studied the effect of pyridoxine administration on levodopa metabolism in four consenting normal and five parkinsonian subjects. Both groups received levodopa, 2 g/day (0.5 g by mouth four times daily) for 2 weeks before simultaneous coadministration of pyridoxine (50 mg by mouth three times daily) for 2 consecutive days. Serial urine collections were made on the day before and during pyridoxine coadministration
Bianchine JR, Hsu TH, Preziosi TJ, et al. Levodopa and Pyridoxine Co-Administration: Differential Metabolie Effect in Parkinsonian and Normal Subjects.. Ann Intern Med. 1973;78:830. doi: https://doi.org/10.7326/0003-4819-78-5-830_2
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Published: Ann Intern Med. 1973;78(5):830.
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