Kenneth A. McKusick, M.D.; Jagmeet S. Soin, M.D.; Wilmot C. Ball Jr., M.D.; Henry N. Wagner Jr., M.D., F.A.C.P.; Malcolm D. Cooper, M.D.
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A major characteristic of radioactive tracer studies of the lung is that they permit measurement of regional as well as total lung function. Because of the potential importance of the early diagnosis of chronic obstructive pulmonary disease, our goal was to determine whether measurement of regional ventilation and perfusion might provide a more sensitive indicator than measurements of total lung function.
Inhaled 133Xe gas and injected 99mTc microspheres were used to measure regional ventilation and perfusion in a population of patients with chronic obstructive pulmonary disease and their asymptomatic family members, who were participants in an epidemiological study of emphysema.
McKusick KA, Soin JS, Ball WC, et al. Measurement of Regional Lung Function in the Early Detection of Chronic Obstructive Lung Disease.. Ann Intern Med. 1973;78:832. doi: https://doi.org/10.7326/0003-4819-78-5-832_1
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Published: Ann Intern Med. 1973;78(5):832.
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