Bertrand J. Shapiro, M.D., F.A.C.P.; Donald P. Tashkin, M.D.; Ira M. Frank, M.D.
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We have previously found that marijuana smoking and ingested delta-9 tetrahydrocannabinol (Δ9 THC) increased specific airway conductance in healthy young men. The response was dose-dependent, with average maximum increases in specific airway conduction of 48% ± 15% at 15 min after smoking of marijuana (assayed at 2% Δ9 THC) and of 45% ± 11% at 180 min after ingestion of 20 mg Δ9 THC. To elucidate the mechanism of bronchodilation, two sets of experiments were performed. In 14 subjects typical marijuana smoking maneuvers were stimulated with slow deep breaths held for 20 to 30 sec over 10 min. Specific airway
Shapiro BJ, Tashkin DP, Frank IM. Mechanism of Increased Specific Airway Conductance with Marijuana Smoking in Healthy Young Men.. Ann Intern Med. 1973;78:832–833. doi: 10.7326/0003-4819-78-5-832_4
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Published: Ann Intern Med. 1973;78(5):832-833.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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