Charley J. Smyth, M.D.; Bruce A. Bartholomew, M.D.; David M. Mills, M.D.; James C. Steigerwald, M.D.
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A controlled 3-year study of 27 patients with rheumatoid arthritis, with cyclophosphamide, showed a marked anti-inflammatory effect. All patients had been refractory to conventional treatment. Weekly or biweekly evaluations were made by using objective measurements of joint inflammation and function. Also, frequent complete blood counts and tests of hepatic and renal function were made; in selected patients immunoresponsiveness and bone marrow studies after 6 months or more of cyclophosphamide therapy. The daily dose was that required to produce leukopenia (2500 to 3000 leukocytes per mm3) or clinical improvement. The average dose was 1.7 mg/kg body weight.
Definite improvement occurred in
Smyth CJ, Bartholomew BA, Mills DM, et al. Cyclophosphamide Therapy of Rheumatoid Arthritis.. Ann Intern Med. 1973;78:833–834. doi: 10.7326/0003-4819-78-5-833_4
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Published: Ann Intern Med. 1973;78(5):833-834.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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